產(chǎn)品屬性：
產(chǎn)品名稱 | Tomatine |
規(guī)格 | 1mg、5mg |
貨號 | EY-01Y16520 |
Cas No.: 17406-45-0
別名: N/A
化學(xué)名: N/A
分子式: C50H83NO21
分子量: 1034.19
溶解度: DMSO: 250 mg/mL (241.74 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity[1].Tomatine inhibits gastric carcinoma cell line (AGS), neuroblastoma cell line (SH-SY5Y) and non-small cell lung cancer cell line (A549) with IC50s of 2 μM, 1.6 μM and 1.1 μM, respectively[1].[1]. da Silva DC, et al. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum. J Steroid Biochem Mol Biol. 2017 Jul;171:178-186.
特別提醒公司產(chǎn)品僅供科研使用
