產(chǎn)品屬性：
產(chǎn)品名稱 | SEC inhibitor KL-1 |
規(guī)格 | 1mg、5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y15029 |
Cas No.: 900308-84-1
別名: N/A
化學(xué)名: N/A
分子式: C18H16ClNO4
分子量: 345.78
溶解度: DMSO: 41.67 mg/mL (120.51 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1].[1]. Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.
特別提醒公司產(chǎn)品僅供科研使用
