產(chǎn)品屬性：
產(chǎn)品名稱 | Spermidine-d6 |
規(guī)格 | 1 mg、5 mg |
貨號 | EY-01Y14916 |
Cas No.: 2514812-10-1
別名: N/A
化學名: N/A
分子式: C7H13D6N3
分子量: 151.3
溶解度: Water: 50 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine.1 It is formed from putrescine by spermidine synthase. Spermidine (25 μM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay.1 It induces autophagy in HeLa cells when used at a concentration of 100 μM and increases the lifespan of D. melanogaster, yeast, and C. elegans.2 Spermidine (30 mM in the drinking water) reduces demyelination of the optic nerve and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).3 It reduces increases in blood pressure, left ventricular posterior wall thickness, and heart weight in salt-sensitive Dahl rats fed a high-salt diet, a model of hypertension-induced congestive heart failure.4 Formulations containing spermidine have been used as dietary supplements.1.Madeo, F., Eisenberg, T., Pietrocola, F., et al.Spermidine in health and diseaseScience359(6374)eaan2788(2018)
2.Eisenberg, T., Knauer, H., Schauer, A., et al.Induction of autophagy by spermidine promotes longevityNat. Cell Biol.11(11)1305-1314(2009)
3.Guo, X., Harada, C., Namekata, K., et al.Spermidine alleviates severity of murine experimental autoimmune encephalomyelitisInvest. Ophthalmol. Vis. Sci.52(5)2696-2703(2011)
4.Eisenberg, T., Abdellatif, M., Schroeder, S., et al.Cardioprotection and lifespan extension by the natural polyamine spermidineNat. Med.22(12)1428-1438(2016)
特別提醒公司產(chǎn)品僅供科研使用
