產(chǎn)品屬性：
產(chǎn)品名稱 | RMC-0331 |
規(guī)格 | 5 mg、10 mg、25 mg、50 mg、100 mg |
貨號 | EY-01Y14624 |
Cas No.: 2488788-52-7
別名: N/A
化學(xué)名: N/A
分子式: C22H25ClF3N5O3
分子量: 499.91
溶解度: DMSO : 125 mg/mL (250.05 mM; Need ultrasonic)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro[1].RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models[1].[1]. Andreas Buckl, et al. Discovery of a Potent, Selective and Orally Bioavailable SOS1 Inhibitor, RMC-0331 (RM-023), an in vivo Tool Compound that Blocks RAS Activation via Disruption of the RAS-SOS1 Interaction.
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