產(chǎn)品屬性：
產(chǎn)品名稱 | RU.521 |
規(guī)格 | 10mM*1mL in DMSO、5mg、10mg、50mg、100mg |
貨號(hào) | EY-01Y14070 |
Cas No.: 2262452-06-0
別名: N/A
化學(xué)名: N/A
分子式: C19H12Cl2N4O3
分子量: 415.23
溶解度: DMSO: ≥ 125 mg/mL (301.04 mM)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
RU.521 (RU320521) is a potent dsDNA and cGAS inhibitor with an IC50 of 700 nM for dsDNA. RU.521 inhibits cGAS-mediated interferon upregulation and suppresses dsDNA-dependent activation. RU.521 is active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS)[1].IC50: 700 nM (dsDNA)[1][1]. Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.
特別提醒公司產(chǎn)品僅供科研使用
