產品屬性：

Cas No.: 495-84-1

別名: N/A

化學名: N/A

分子式: C13H11N3O2

分子量: 241.2

溶解度: DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.23 mg/ml,DMSO: 5 mg/ml

儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

SIH is a lipophilic cell-permeable iron chelator.1,2 It stimulates iron release from, and inhibits iron uptake by, SK-N-MC human neuroblastoma cells when used at a concentration of 25 μM.3 SIH inhibits cumene hydroperoxide-induced membrane lipid peroxidation but not ABAP-induced formation of cytosolic peroxyl radicals in HepG2 human hepatocellular carcinoma cells (IC50s = 0.833 and >4,000 μM, respectively).1 It inhibits hydrogen peroxide-induced mitochondrial membrane depolarization in H9c2 rat cardiomyocytes (EC50 = 0.8 μM).2 SIH (1.0 mg/kg) completely prevents mortality in a rabbit model of cardiotoxicity induced by chronic administration of daunorubicin .41.Hofer, T., J?rgensen, T.?., and Olsen, R.L.Comparison of food antioxidants and iron chelators in two cellular free radical assays: Strong protection by luteolinJ. Agric. Food Chem.62(33)8402-8410(2014)

2.?im?nek, T., Boer, C., Bouwman, R.A., et al.SIH—a novel lipophilic iron chelator—protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell deathJ. Mol. Cell. Cardiol.39(2)345-354(2005)

3.Wu, Z., Palanimuthu, D., Braidy, N., et al.Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD+ /NADH ratiosBr. J. Pharmacol.177(9)1967-1987(2019)

4.?t?rba, M., Popelová, O., ?im?nek, T., et al.Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH)Toxicology235(3)150-166(2007)
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