產品屬性：
產品名稱 | TH588 hydrochloride |
規(guī)格 | 5mg、25mg、50mg、100mg |
貨號 | EY-01Y13083 |
Cas No.: 1640282-30-9
別名: N/A
化學名: N/A
分子式: C13H13Cl3N4
分子量: 331.63
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM [1].Cell Viability Assay[1] Cell Line:U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cellsTH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model[1].Animal Model:5-6 weeks female SCID mice (SW480 xenograft cancer model)[1][1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.
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