產(chǎn)品屬性：
產(chǎn)品名稱 | Theliatinib |
規(guī)格 | 1mg、5mg、10mg、25mg、50mg、100mg |
貨號(hào) | EY-01Y12813 |
Cas No.: 1353644-70-8
別名: N/A
化學(xué)名: N/A
分子式: C25H26N6O2
分子量: 442.51
溶解度: DMSO: 5 mg/mL (11.30 mM)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Theliatinib (HMPL-309) is a potent, ATP-competitive and highly selective EGFR inhibitor, significantly inhibits phosphorylation of EGFR (p-EGFR) and its downstream targets, AKT and ERK (p-AKT and p-ERK), with anti-tumor activity. Theliatinib (HMPL-309) shows a Ki of 0.05 nM for wild type EGFR, and IC50s of 3 and 22 nM for EGFR and EGFR T790M/L858R mutant, respectively[1].[1]. Ren Y, et al. Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification. Oncotarget. 2017 Apr 19;8(31):50832-50844.
特別提醒公司產(chǎn)品僅供科研使用
