產(chǎn)品屬性：
產(chǎn)品名稱 | Resolvin D1 |
規(guī)格 | 10 μg、25 μg、50 μg、100 μg |
貨號 | EY-01Y11772 |
Cas No.: 872993-05-0
別名: 17(S)-Resolvin D1, RvD1
化學(xué)名: 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid
分子式: C22H32O5
分子量: 376.5
溶解度: 50mg/mL in DMF, 50mg/mL in Ethanol
儲存條件: Store at -80°C,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] A 17(R)-epimer of RvD1 can also be generated in aspirin-treated samples.[3] Both RvD1 and its 17(R)-configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM.4 RvD1 and its aspirin-triggered form also exhibit a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.[4] Analytical and biological comparisons of synthetic RvD1 with endogenously derived RvD1 have confirmed its identity as matching the natural product.[5]
特別提醒公司產(chǎn)品僅供科研使用
