產(chǎn)品屬性：
產(chǎn)品名稱 | RO-5963 |
規(guī)格 | 100mg、250mg、500mg |
貨號 | EY-01Y10959 |
Cas No.: 1416663-77-8
別名: N/A
化學(xué)名: N/A
分子式: C24H21ClF2N4O5
分子量: 518.9
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM, respectively[1].IC50: ~17 nM (p53-MDM2), ~24 nM (p53-MDMX)[1]RO-5963 (10-20 μM; 48 hours) shows much higher apoptotic activity than Nutlin in both MCF7 and ZR75-30 cell lines[1].RO-5963 (10 μM, 24 hours) effectively activats p53 and elevates p21 and MDM2 levels[1].Apoptosis Analysis[1] Cell Line:ZR75-30, MCF7 cells[1]. Graves B, et al. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93.
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