產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | SRI-011381 |
規(guī)格 | 500μg、1mg、5mg、10mg |
貨號(hào) | EY-01Y10878 |
Cas No.: 1629138-41-5
別名: N/A
化學(xué)名: N/A
分子式: C20H31N3O
分子量: 329.5
溶解度: DMF: 15mg/mL,DMSO: 20mg/mL,Ethanol: 25mg/mL,Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
SRI-011381 is an activator of TGF-β signaling.1 It reduces increases in cell death and the number of dystrophic neurites induced by amyloid-β (1-42) in primary mouse embryonic forebrain neurons when used at a concentration of 3 μM. SRI-011381 (2 and 5 μM) increases phagocytosis of Aβ42 by greater than 20% in J774A.1 and THP-1 macrophages. It increases contextual fear conditioning freezing time and spontaneous alternations in the Y-maze, indicating prevention of memory deficits, in the APP751Lon,Swe transgenic mouse model of Alzheimer's disease when administered at a dose of 10 mg/kg for 10 weeks.
特別提醒公司產(chǎn)品僅供科研使用
