產(chǎn)品屬性：
產(chǎn)品名稱 | SMU127 |
規(guī)格 | 500 μg、1 mg、5 mg |
貨號 | EY-01Y10685 |
Cas No.: 903864-87-9
別名: N/A
化學(xué)名: N/A
分子式: C16H23N3O3S
分子量: 337.4
溶解度: DMF: 1 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: slightly soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.1 It induces NF-κB signaling in cells expressing human TLR2 (EC50 = 0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 μM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 μM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.1.Chen, Z., Cen, X., Yang, J., et al.Structure-based discovery of a specific TLR1-TLR2 small molecule agonist from the ZINC drug library databaseChem. Commun. (Camb.)54(81)11411-11414(2018)
特別提醒公司產(chǎn)品僅供科研使用
