產品屬性：
產品名稱 | Sulfamoxole |
規(guī)格 | 25mg、50mg、100mg、250mg |
貨號 | EY-01Y10263 |
Cas No.: 729-99-7
別名: N/A
化學名: N/A
分子式: C11H13N3O3S
分子量: 267.3
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Sulfamoxole is a sulfonamide antibiotic.1 It is inactive or weakly active against bacteria when used alone but acts synergistically with trimethoprim against a variety of bacteria in vitro, including strains of S. pyogenes, E. coli, and P. vulgaris when used at concentrations of 1.95-7.8, 0.12-1.95, and 0.48-0.97 μg/ml, respectively. Sulfamoxole, in combination with trimethoprim, is effective in mouse models of E. coli or P. vulgaris infection. It inhibits P. carinii recombinant dihydropteroate synthase (DHPS), an enzyme required for the biosynthesis of folate, with an IC50 value of 0.089 μM.2|1. B?hni, E. Bacteriostatic and bactericidal activity of two trimethoprim-sulfonamide combinations. Chemotherapy 22(3-4), 262-273 (1976).|2. Hong, Y.-L., Hossler, P.A., Calhoun, D.H., et al. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob. Agents Chemother. 39(8), 1756-1763 (1995).
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